Download 31st Hemophilia Symposium Hamburg 2000: Epidemiology by I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, PDF

By I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)

Some 23. five% of all participants and sufferers of remedy facilities accomplished the questionnaire. One extraordinary truth is that participation used to be maximum among aged sufferers with critical hemophilia, while basically 12. 2% of family spoke back. review of the implications published that almost all of contributors favor deal with­ ment in a hemophilia therapy heart with a excessive recognition, while in basic terms 2. 7% examine remedy in a really expert perform to be enough. the explanations for which are the need of the 24-h-availability of a doctor, usual certified exam of joints and muscle tissues, documentation of product batches, laboratory exams and solid cooperation with different schools. As many as sixty eight. nine% of the sufferers occasionally go back and forth greater than 2 hundred km. What definitely performs a task this is belief within the therapy heart and its physicians, for it really is seen that without reference to the truth that seventy four. three% re­ quested standardized therapy regimens for all therapy facilities, purely approximately 20% may switch to a closer heart. therapy with issue concentrates is mostly thought of to be very secure. that's to assert, fifty eight. 1 % regard recombinant items to be very secure, while purely 24. three% suppose this for plasma items. when put next, there have been frequently no significant ameliorations saw relating to end result (factor intake, length of deal with­ ment). elevate in greatest garage temperature (47. 2%) and half-life (73%) have been the main widespread solutions to the query of what positive aspects the goods should still have.

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Extra info for 31st Hemophilia Symposium Hamburg 2000: Epidemiology Inhibitors in Hemophilia Therapy and Monitoring of Bleeds in Acute and Intensive Care Medicine Pediatric Hemostaseology Case Reports

Example text

Test plasma dilutions were incubated with FVIII concentrate (rFVIII, Recombinate, Baxter) and FVIII concentrate containing vWF (FVIII-vWF, Haemoctin SDH, Biotest). The residual FVIII:C activity was measured by chromogenic method. Each data point represents the mean of two individual experiments 32 A. Kallas et al. ::! c r::: c( 40 20 0 0 2 4 6 8 10 Recombinant fragment, IU/ml 12 14 Fig. 5. Neutralization of FVIII antibodies from plasma sample from patient 1 taken before ITT. Plasma sample was diluted to 4 BUlml and incubated with increasing concentration of recombinant FVIII light chain (rLCh) and heavy chain (rHCh).

The results of FVIIILCh:Ab IgG subtypes are shown in Table l. The higher relative amount of FVIII-LCh antibodies belonged to IgG4 subtype. The level of FVIII light chain antibodies decreased in the order IgG4> IgG 1> IgG3> IgG2 and was similar to subtype distribution of antibodies against a FVIII whole molecule. OI). OI). Changes in FVIII:Ab IgG Subtype Distribution During the Treatment with Different FVIII Concentrates One low responder hemophilia A patient (patient 2, Fig. 3) was treated with plasma derived FVIII concentrates of different purity for a long time.

Since the beginning of the survey in 1982 a total of 654 patients have been reported dead. As compared to the peak of 60 deaths in the 94/95 period a decrease of 66,7% occurred in the 99/00 period. The development of mortality and causes of death since 82/83 are depicted in Fig. 7. Up to 1995 the number of AIDS-related deaths increased continuously with decline taking place since. Fortunately AIDS-related deaths again receded this year. The main reason for this development can probably be attributed to improved antiretroviral therapies.

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